Polyene antibiotics. IX. An improved method for the preparation of methyl esters of polyene antibiotics.

Methyl esters of trimethylammonium derivatives of polyene macrolide antibiotics.

The polyene macrolide antibiotics.

The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.

Polyene Antifungal Antibiotics

ZYGMUNT, WALTER A. (Mead Johnson Research Center, Evansville, Ind.). Intracellular loss of potassium in Candida albicans after exposure to polyene antifungal antibiotics. Appl. Microbiol. 14:953-956. 1966.-Eleven antifungal antibiotics, representing three broad macrolide classes, were studied in Candida albicans for their effect on growth and on the fate of intracellular K+. Marked differences ...

N-glycosyl derivatives of polyene macrolide antibiotics.

Sir: The polyene macrolides are known as potent antifungal agents. However their use in therapy is limited by considerable toxicity and very poor water solubility. Many efforts had been taken to obvert these undesirable properties1-5). We report now a new group of derivatives of polyene macrolides exhibiting improved solubility in water and organic solvents and retaining the biological activity...

The mechanism of the hemolytic activity of polyene antibiotics.

The kinetics of the filipin-, amphotericin B- and nystatin-induced hemolysis of human erythrocytes were investigated. Filipin-induced hemolysis is of the damage type. It is an all-or-none process, partly inhibited by Ca2+ or Ba2+ but not by Mg2+, Na+ or SO42-. The hemolytic activity of filipin is explained by the formation of large aggregates within the erythrocyte membrane in the form of large...